New treatment paradigms in oligometastatic disease (#29)
Background/ Significance:
The term “oligometastases” was coined in 1995 by Hellman and Weichselbaum to describe a state of ordered metastatic progression which precedes widely disseminated disease. In the oligometastatic concept, local aggressive management is thought to alter the systemic course of disease. Successful pulmonary metastasectomy in the setting of renal carcinoma was first reported in 1939 by the surgeon Barney in a patient who died 23 years later without evidence of disease. In this presentation, we revisit the principles of local treatments of oligometastatic disease, and consider new paradigms of management in this clinical setting.
Objectives:
To discuss potentially curative options for metastatic disease from urogenital malignancies, with a focus primarily on renal cell carcinoma and secondarily on prostate cancer and other urogenital malignancies. The evidence base for surgery, stereotactic ablative body radiotherapy (SABR) and radiofrequency ablation (RFA) will be discussed. Two major concepts will be visited;
1. Potentially curative treatment in patients with oligometastases
2. Treatment of minimal metastatic disease in order to delay onset / change of systemic chemotherapy