Background:

I completed a one-year clinical uro-oncology fellowship in Vancouver in 2008, during which I developed a keen interest in clinical research, but did not initiate any trials. I am now a full-time practising clinical urologist in both public and private systems, with an interest in oncology. Due to constraints of time and trial expertise, I have only been able to undertake and supervise minor clinical research projects.

One such project was a pilot study of using a novel analgesic agent (methoxyflurane – Penthrox™) for TRUS biopsy of the prostate. This study showed evidence of safety and potential efficacy and was published. I was keen to test it further on a larger scale, but did not have the resources to do so.

Method:

In 2012, ANZUP invited submissions to a new session at its ASM in Sydney. These submissions were to be made for presentation of an idea for a clinical trial, with a view to possible development through ANZUP. I submitted my concept for a multi-centre randomized control trial comparing Penthrox versus the current gold standard of local anaesthetic infiltration for analgesia in TRUS biopsy, and it was accepted.

I presented my concept to the conference. Judging by the feedback, there was clearly interest in the idea, and it was suggested that it might be suitable as a trial to be run through ANZUP.

Results:

Interested ANZUP members approached me for further discussion, a working party was formed, and a series of teleconferences ensued. The working party consisted of ANZUP members with expertise in trial design and grant application. Together we crystallised the trial plan, gathered members to collaborate as associate investigators, and submitted a $600,000 grant application.

Conclusion: